Abstract
Hypophysectomy was found to decrease the cAMP-dependent and independent protein kinase
activity in adipose tissue and isolated adipocytes, as observed with protamine or
histone substrates. Hypophysectomy did not affect the sensitivity of protein kinase
to cAMP at various nucleotide concentrations. Adipose tissue was shown to contain
a considerable phosphoprotamine phosphatase activity which was not affected by hypophysectomy.
The data presented suggest that the decreased protein kinase activity may be, at least
partly, responsible for the decreased cAMP-induced activation of lipase in adipose
tissue of hypophysectomized rats.
Key words
Protein Kinase - Adipose Tissue - Hypophysectomy
1 Present address: Department of Biochemistry, Hebrew University - Hadassah Medical
School, Jerusalem, Israel
